The aim of this study was to analyze changes in myocardial contractility as assessed by regional and global longitudinal strain in patients undergoing chemotherapy for breast cancer. Clinical Cardiology. Differentiating between reduction in GLS due to clinical change and normal temporal variability in measurement remains a challenge. By Michael H. Crawford, MD, Editor. Global longitudinal strain (GLS) by speckle tracking echocardiography seems to be an important additive method for evaluation of LV function with improved reproducibility compared with LVEF. 16 cardiac troponin i (ctni) is a sensitive and specific marker of myocardial injury, and troponin elevation during chemotherapy administration has been associated with ⦠JAMA Cardiol 2019;Aug 21:[Epub ahead of print]. Persistently reduced strain was observed in 16% who had a greater reduction in strain in 6 months (⤠-17.2%), and had received higher cumulative anthracycline doses ( 24 ). Global longitudinal strain (%) will be used to assess changes in cardiac contractile function and be measured by echocardiogram at pre-surgery, pre-chemotherapy, and post-chemotherapy Ejection Fraction [ Time Frame: 22 weeks ] Baseline LVEF, RV fractional area change (RV FAC), RV free wall strain (RV FWS), and RV global longitudinal strain (RV GLS) were measured prior to chemotherapy initiation and compared with echo studies obtained at a 6-month follow-up ⦠Assessment of Prognostic Value of Left Ventricular Global Longitudinal Strain for Early Prediction of Chemotherapy-Induced Cardiotoxicity: A Systematic Review and Meta-Analysis. Right ventricle (RV) function has been recognized as an independent factor for cardiac outcomes; however, data evaluating RV GLS is limited. The polar map showing the time to peak longitudinal strain is displayed. 8,9. Explore and learn more about Conference Series LLC LTD: World’s leading Event Organizer Sawaya H, Sebag IA, Plana JC, et.al. Similarly, Bi et al demonstrated a significant early reduction of longitudinal strain after treatment with epirubicin . J Am Soc Echocardiogr. 2016;29:522â527.e3. Hatazawa K, Tanaka H, Nonaka A, et al. Baseline global longitudinal strain as a predictor of left ventricular dysfunction and hospitalization for heart failure of patients with malignant lymphoma after anthracycline therapy. Echocardiographic left ventricular global longitudinal strain (GLS) detects early subclinical ventricular dysfunction and can be used in patients receiving potentially cardiotoxic chemotherapy. Assessment of prognostic value of left ventricular global longitudinal strain for early prediction of chemotherapy-induced cardiotoxicity: a systematic review and meta-analysis. The load dependence of global longitudinal strain (GLS) means that changes in systolic blood pressure (BP) between visits may confound the diagnosis of cancer-treatment-related cardiac dysfunction (CTRCD). Echocardiography, Chemotherapy-induced cardiotoxicity, Global lon-gitudinal strain, Chemotherapy GLS is assessed using automated speckle-tracking echocardiography to detect and quantify subtle disturbances in left ventricular systolic function. Echocardiographic measurements including left ventricular global longitudinal strain (LVGLS) and peak atrial longitudinal strain (PALS) decline were compared. Radiotherapy for breast cancer (BC) and its resulting cardiac exposure are associated with subclinical left ventricular dysfunction characterized by early decrease of global longitudinal strain (LS) measurement based on 2D speckle-tracking echocardiography. Key words: cardiotoxicity, chemotherapy, echocardiography, global longitudinal strain Breast cancer is the most common malig-nancy among women, accounting for one in three cancers among women in the United States.1 In patients with the aggressive HER-2 positive breast cancer, trastuzumab (TRZ), espe-cially when combined with anthracyclines (AC), The load dependence of global longitudinal strain (GLS) means that changes in systolic blood pressure (BP) between visits may confound the diagnosis of cancer-treatment-related cardiac dysfunction (CTRCD). Eur Heart J Cardiovasc Imaging . Longitudinal strain is an echocardiographic bedside method to assess the regional and global left ventricular function. It has been shown to demonstrate myocardial damage earlier in treatment than 2DEF, allowing the option of pharmacological intervention at a pre-clinical stage and preventing the interruption of Herceptin. The aim of this study was to test the relative value of new indices of myocardial work and global longitudinal strain (GLS) in detecting changes in myocardial function during the treatment of breast cancer by two-dimensional and three-dimensional echocardiography. The left panels show the direction (arrows demonstrate the direction) in which various strain parameters are being measured. A meta-analysis of the prognostic value of GLS for cancer therapy-related cardiac dysfunction (CTRCD) has not been performed, to our knowledge. Early detection and prediction of cardiotoxicity in chemotherapy-treated patients. It affects an estimated 48 million women, with the highest prevalence of infertility affecting women in South Asia, Sub-Saharan Africa, North Africa/Middle East, and Central/Eastern Europe and Central Asia. Abstract. LV dysfunction after anthracycline chemotherapy was defined according to the ⦠2 Department of Medicine, Division of Cardiovascular Medicine, University of Missouri-Columbia, Columbia, Missouri USA. The global longitudinal strain (GS) was â13.1%, while the left ventricular mechanical dispersion (PSD) was 60.3 ms. Important inter-vendor variability of GLS measurements has been reported in ⦠Recently, Englewood Hospital has started evaluating cancer patients for earlier signs of heart dysfunction using a newer measurement called left ventricular global longitudinal strain (GLS). Negishi et al. The aim of this study was to analyze changes in myocardial contractility as assessed by regional and global longitudinal strain in patients undergoing chemotherapy for breast cancer. CIC was defined as a decrease in LVEF to <53%. Prognostic Value of Global Longitudinal Strain for Early Prediction of Chemotherapy-Induced Cardiotoxicity JN Learning⢠is the home for CME and MOC from the JAMA Network. Full PDF Package Download Full PDF Package. The aim of this study was to analyze changes in myocardial contractility as assessed by regional and global longitudinal strain in patients undergoing chemotherapy for breast cancer. Global longitudinal strain can also monitor cardiotoxicity during chemotherapy treatment. to Initiation of Cytotoxic Chemotherapy (A) Global longitudinal strain (GLS), (B) global radial strain (GRS), and (C) global circumferential strain (GCS). Global longitudinal strain (GLS) is the best studied strain parameter with the largest body of literature supporting its diagnostic and prognostic value . Clément Charbonnel, Raphaele Convers-Domart, Sophie Rigaudeau, Anne Laure Taksin, Nicolas Baron, Juliette Lambert, Stéphanie Ghez, Jean-Louis Georges, Hassan Farhat, Jérôme Lambert, Philippe Rousselot, Bernard Livarek, Assessment of global longitudinal strain at low-dose anthracycline-based chemotherapy, for the prediction of subsequent cardiotoxicity, ⦠Despite high effectiveness of Anthracycline as a potent antineoplastic agent, its-related cardiothoxicity is the most notorious complication. Right ventricle (RV) function has been recognized as an independent factor for cardiac outcomes; however, data evaluating RV GLS is limited. Am J Cardiol. Prior to chemotherapy initiation, baseline strain echocardiography was performed at Cleveland Clinicâs Cardio-Oncology Center, which revealed a left ventricular ejection fraction (LVEF) of 65 percent with global longitudinal strain of â25.5 percent (Figure 1). It is unclear whether the first chemotherapy cycle would cause GLS and RLS reduction and which segment would be most affected by the ⦠Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 1000+ Conferences, 1000+ Symposiums and 1000+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business.. Conclusions: Global longitudinal strain is an echocardiographic index of myocar-dial performance, which presented a significant discriminating value with respect to cardiotoxicity in patients who received chemotherapeutic treatment. Early detection and prediction of cardiotoxicity in chemotherapy-treated patients. Utility of Global Longitudinal Strain by Echocardiography to Detect Left Ventricular Dysfunction in Long-Term Adult Survivors of Childhood Lymphoma and Acute Lymphoblastic Leukemia. Patients were classified according to the 2015 ASE/EACVI criteria as having impaired myocardial deformation when GLS was reduced (less negative), with a cutoff of -18%. In this case–control study, ⦠There are no data on the use of GLS in ICI myocarditis. Left ventricular (LV) global peak systolic longitudinal strain (GLS) is a sensitive measurement for detecting subtle LV systolic dysfunction and a ⦠Echocardiographic global longitudinal strain (GLS) has been recommended as a means to follow patients at risk of cancer chemotherapy-related left ventricular (LV) systolic ⦠On a review of the literature examining the prognostic value of strain imaging in chemotherapy patients, an early decrease of 10-11% (95% confidence interval, 8-15%) in global longitudinal strain predicts cardiotoxicity. Introduction. A meta-analysis of the prognostic value of GLS for cancer therapyârelated cardiac dysfunction (CTRCD) has not been performed, to our knowledge. Still, many controversies exists that limit its evaluation, so this study is a contribution to this need for practicality. We sought to determine whether the estimation of myocardial work, which incorporates SBP, could overcome this limitation. SYNOPSIS: Using left ventricular peak systolic global longitudinal strain vs. left ventricular ejection fraction to survey patients undergoing potentially cardiotoxic chemotherapy with at least one other risk factor for heart failure showed no difference in the primary endpoint of the difference in ejection fraction between the two groups ⦠Results: CTRCD was identified in 13 patients (18.1%) after additional trastuzumab therapy. global longitudinal strain and has been shown to improve reliability in the measurement of LVEF. Echocardiographic global longitudinal strain (GLS) has been recommended as a means to follow patients at risk of cancer chemotherapy-related left ventricular (LV) systolic dysfunction. Several chemotherapy agents, but in particular adriamycin, are known to cause cardiomyopathy. 1 Global longitudinal strain (GLS), assessed by 2-dimensional speckle tracking echocardiography, has emerged as a new method for assessing left ventricular (LV) function. 1,2 Ever since the first reports of possible cardiotoxic effects from anti-cancer agents, ... particularly the use of longitudinal deformation measures and the global longitudinal strain (GLS) value. press to zoom. The resulting ROI includes the pericardium and, therefore, underestimates the peak longitudinal strain (B) (Online Videos 2A and 2B). The time to peak longitudinal strain curves are displayed in the APLAX, two-chamber (2CH) and four-chamber (4CH) views (white arrows). Objectives: This study sought to evaluate the role of GLS and assess its association with cardiac events among patients with ICI myocarditis. Introduction: Is well known the usefulness of left ventricle (LV) longitudinal global strain (GLS) in patients receiving antineoplastic therapy but studies suggested a similar behavior of the right ventricle (RV) free wall longitudinal strain (FWLS). Global longitudinal strain (GLS) is used to evaluate left ventricular (LV) performance after chemotherapy. JACC Cardiovasc Imaging 2015;8:1351-9. JACC Cardiovasc Imaging 2015;8:1351-9. 1 Houston Methodist DeBakey Heart and Vascular Center, 6550 Fannin St., Suite 1901, Houston, Texas 77030 USA. Cardiovascular disease remains a leading cause of death and disability, responsible for 31% of all deaths. Global longitudinal strain is a measure of myocardial deformation that can detect early changes in cardiac function prior to LVEF reduction.
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